Retinoids: an overview of some natural carotenoid metabolites and their synthetic analogs
نویسندگان
چکیده
Retinoids are very effective compounds for the control of both cellular differentiation and cellular proliferation. New synthetic analogs show pronounced activity in suppressing experimental carcinogenesis jji !.L.Q by inhibiting the development of the malignant phenotype in a non-cytotoxic manner. Beside the extensive use of retinoids in dermatology they are currently being tested for the prevention and therapy of cancerous diseases in man. Whether increased consumption of 13—carotene, the precursor of natural retinoids, can prevent cancer is being evaluated in clinical intervention trials.
منابع مشابه
Pharmacological properties of some 3-substituted indole derivatives, a concise overview
Indole is a nitrogen-containing heterocycle. It is a very important motif in agriculture and pharmacy. Many compounds containing indole moiety has been isolated form nature. It is also an important part in natural alkaloids. Tryptophan is an amino acid which posses indole. 3-Sustituted indoles are the main group of its derivatives. Because the wide-spread application of 3-substituted indolic co...
متن کاملIn silico identification of miRNAs and their target genes and analysis of gene co-expression network in saffron (Crocus sativus L.) stigma
As an aromatic and colorful plant of substantive taste, saffron (Crocus sativus L.) owes such properties of matter to growing class of the secondary metabolites derived from the carotenoids, apocarotenoids. Regarding the critical role of microRNAs in secondary metabolic synthesis and the limited number of identified miRNAs in C. sativus, on the other hand, one may see the point how the characte...
متن کاملA review of three systemic retinoids in dermatology: acitretin, isotretinoin and bexarotene
Retinoids are synthetic and natural analogues of vitamin A that have various effects on cellular differentiation, cellular proliferation, immune system, and embryonic development. The present study reviews the history of systemic retinoids in medicine, the structure of syn
متن کاملRetinoids, retinoid-responsive genes, cell differentiation, and cancer.
Vitamin A (retinol), its natural and synthetic derivatives, and its metabolites are known collectively as retinoids (Fig. 1). Vitamin A is required in the diets of vertebrate animals, and vitamin A is oxidized to RA,2 a compound that exerts dramatic effects on vertebrate development and cell differentiation. In addition, retinoids can inhibit or reverse the process of malignant transformation i...
متن کاملInfluence of Natural Sources of Biologically Active Substances on Livestock and Poultry Reproduction
Synthetic hormones and bioactive substances (vitamins, pigments and isoflavons) which have been used in the feed industry are accumulated in milk, meat and eggs. It is suspected that these are responsible for a number of side-effects such as carcinogenesis, liver and kidney damage, allergies in consumers. Furthermore the synthetic hormones, vitamins, pigments are less active than those extracte...
متن کامل